50 Fresh Immunology Dissertation Topics

Immunology Dissertation Topics

If you’re planning to write your dissertation in immunology, the right topic can give your research a solid direction. To make things easier, here’s a list of 50 fresh immunology dissertation topics that you can explore in 2025.

Topics

• Role of innate immunity in viral clearance
  
• Advances in tumour immunotherapy strategies
  
• Epigenetic regulation of immune responses
  
• Gut microbiota influence on immune system development
  
• Molecular mechanisms of autoimmune diseases
  
• Immunological memory in vaccine responses
  
• T-cell exhaustion in chronic infections
  
• Impact of stress on immune function
  
• The role of dendritic cells in antigen presentation
  
• Nanoparticle-based vaccine delivery systems
  
• Immunopathology of COVID-19 variants
  
• B-cell receptor signalling in antibody diversity
  
• Checkpoint inhibitors in cancer therapy
  
• Ageing and immune system decline
  
• Cross-reactivity in viral immunity
  
• Role of interferons in antiviral defence
  
• Genetic predisposition to autoimmune disorders
  
• Development of universal flu vaccines
  
• Impact of obesity on immune responses
  
• Environmental pollutants and immune system impairment
  
• Regulatory T cells in immune tolerance
  
• Cytokine storms in infectious diseases
  
• Adaptive immunity in parasitic infections
  
• Sex differences in immune responses
  
• Immune escape mechanisms in tumours
  
• Novel adjuvants for vaccine enhancement
  
• Immunological aspects of organ transplantation
  
• Trained immunity and its therapeutic potential
  
• MicroRNAs in immune regulation
  
• Role of the thymus in T-cell development
  
• Immunotherapy resistance in melanoma
  
• Genetic engineering of CAR-T cells
  
• Cross-protection in flavivirus infections
  
• Allergy development and immune dysregulation
  
• Maternal immunity transfer during pregnancy
  
• Neonatal immune system development
  
• Role of NK cells in viral infections
  
• Antibody engineering for infectious diseases
  
• Host–pathogen interactions in tuberculosis
  
• Autoantibody formation in systemic lupus erythematosus
  
• Impact of sleep deprivation on immunity
  
• Role of inflammasomes in chronic diseases
  
• Immunological markers for early cancer detection
  
• Immune evasion strategies of HIV
  
• Interaction between diet and immune regulation
  
• Advances in mRNA vaccine technology
  
• Role of complement system in immunity
  
• The impact of probiotics on immune modulation
  
• Nanomedicine approaches in immunotherapy
  
• Targeting immune checkpoints beyond PD-1 and CTLA-4
  

These dissertation topics in immunology cover emerging areas, clinical applications, and experimental approaches. Each idea can be shaped into a full research project depending on your interest and academic requirements.